Prof. Dr. Muhammad Furqan Bari

Research

Histopathology, Biomarkers, Reproductive endocrinology

ResearchGate/ORCID link:

List of Selected Research Publications (with DOI citation):

Khan N, Bari MF, Shabbir A, Abbas FF, Farooqui WA, Razzaq A. Prognosis of non-small cell lung cancer in relation to the smoking status in a tertiary care hospital, Karachi, Pakistan. RMJ. 2024; 49(2): 302-305.

Abbas FF, Bari MF, Mughal MN, Khan BA, Khan N, Kamil S, Razzaq A, Kamil N. Mutational Analysis of EZH2 in the Germinal Centre Type of Diffuse Large B Cell Lymphoma. J Liaq Uni Med Health Sci [Internet]. 2024 Apr. 3 [cited 2024 Apr. 25];23(01):15-20. Available from: http://ojs.lumhs.edu.pk/index.php/jlumhs/article/view/1173

Bibi I, Hanif F, Amir Q, Washdev W, Bari MF. Impact of Brain derived Neurotrophic factor gene polymorphism on its peripheral levels in schizophrenic patients. J Pak Med Assoc. 2024 Feb;74(1 (Supple-2)):S19-S24. doi: 10.47391/JPMA-DUHS-S05. PMID: 38385466.

Haider SI, Riaz Q, Bari MF. Development and Evaluation of a Peer Mentoring Programme for Postgraduate Medical Residents in Pakistan: A Pilot Study. J Coll Physicians Surg Pak. 2023 Nov;33(11):1305-1309. doi: 10.29271/jcpsp.2023.11.1305. PMID: 37926886. (Impact Factor= 1.0)

Salam H, Ahmed S, Bari MF, Bukhari U, Haider G, Najeeb S, Mughal N. Association of Kaiso and partner proteins in oral squamous cell carcinoma. J Taibah Univ Med Sci. 2022 Dec 30;18(4):802-811. doi: 10.1016/j.jtumed.2022.12.013. PMID: 36852243; PMCID: PMC9957818. (Impact Factor= 2.2)

Ahmed MA, Nazim F, Ahmed K, Bari MF, Abdulwahed A, AlMokhatieb AA, Alalvi Y, Abduljabbar T, Mughal N, Abidi SH. Association between the baseline gene expression profile in periapical granuloma and periapical wound healing after surgical endodontic treatment. Sci Rep. 2022 Aug 15;12(1):13824. doi: 10.1038/s41598-022-17774-z. PMID: 35970906; PMCID: PMC9378616. (Impact Factor= 4.99)

Tersigni C, Furqan Bari M, Cai S, Zhang W, Kandzija N, Buchan A, Miranda F, Di Simone N, Redman CW, Bastie C, Vatish M. Syncytiotrophoblast-derived extracellular vesicles carry apolipoprotein-E and affect lipid synthesis of liver cells in vitro. J Cell Mol Med. 2022 Jan;26(1):123-132. doi: 10.1111/jcmm.17056. Epub 2021 Dec 10. PMID: 34894055; PMCID: PMC8742183. (Impact Factor= 5.310)

Ahmed MA, Mughal N, Abidi SH, Bari MF, Mustafa M, Vohra F, Alrahlah A. Factors Affecting the Outcome of Periapical Surgery; a Prospective Longitudinal Clinical Study. Applied Sciences. 2021; 11(24):11768. https://doi.org/10.3390/app112411768 (Impact Factor= 2.842)

Ashfaque A, Hanif F, Simjee SU, Bari MF, Faizi S, Zehra S, Mirza T, Begum S, Khan L. Opuntiol Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells by Upregulating Active Caspase 3 Expression. Asian Pac J Cancer Prev. 2021 Nov 1;22(11):3607-3613. doi: 10.31557/APJCP.2021.22.11.3607. PMID: 34837919; PMCID: PMC9068190. (Impact Factor= 1.6)

Ahmed MA, Anwar MF, Ahmed K, Aftab M, Nazim F, Bari MF, Mustafa M, Vohra F, Alrahlah A, Mughal N, Abidi SH. Baseline MMP expression in periapical granuloma and its relationship with periapical wound healing after surgical endodontic treatment. BMC Oral Health. 2021 Nov 3;21(1):562. doi: 10.1186/s12903-021-01904-6. PMID: 34732191; PMCID: PMC8565031. (Impact Factor= 2.757)

Shahid R, Bari MF, Hussain M. Serum biomarkers for the prediction and diagnosis of preeclampsia: A meta-analysis. J Taibah Univ Med Sci. 2021 Aug 11;17(1):14-27. doi: 10.1016/j.jtumed.2021.07.003. PMID: 35140561; PMCID: PMC8802864. . (Impact Factor= 2.2)

Shahid R, Abbas H, Mumtaz S, Bari MF, Ahmed N, Memon S, Raja T, Dawani K. Emergency Obstetric Hysterectomy, the Histopathological Perspective: A Cross-Sectional Study From a Tertiary Care Hospital. Cureus. 2020 Jul 9;12(7):e9094. doi: 10.7759/cureus.9094. PMID: 32789042; PMCID: PMC7417067.

Haider SI, Gondol KM, Tariq M, Bari MF, Azam I. Reliability and Validity of WATCH: Warwick Assessment InsTrument for Clinical TeacHing. J Coll Physicians Surg Pak. 2020 Jun;30(6):633-637. doi: 10.29271/jcpsp.2020.06.633. PMID: 32703350. (Impact Factor= 1.0)

Shahid R, Abbas H, Mumtaz S, Perveen F, Bari MF, Raja T, Memon S, Ahmed N, Dawani K. Hysterectomy and Oophorectomy in Reproductive Age: A Cross-Sectional Study from a Tertiary Care Hospital. Cureus. 2020 May 28;12(5):e8344. doi: 10.7759/cureus.8344. PMID: 32617218; PMCID: PMC7325352.

Haider SI, Bari MF, Ijaz S. Using Multiple Mini-Interviews for Students' Admissions in Pakistan: A Pilot Study. Adv Med Educ Pract. 2020 Mar 6;11:179-185. doi: 10.2147/AMEP.S246285. PMID: 32184697; PMCID: PMC7064286. (Impact Factor= 4.0)

Msheik H, El Hayek S, Bari MF, Azar J, Abou-Kheir W, Kobeissy F, Vatish M, Daoud G. Transcriptomic profiling of trophoblast fusion using BeWo and JEG-3 cell lines. Mol Hum Reprod. 2019 Dec 1;25(12):811-824. doi: 10.1093/molehr/gaz061. PMID: 31778538. (Impact Factor= 4.0)

Khan N, Mirza T, Zuberi FF, Bari MF. Expression of TTF-1, NAPSIN-A, P63 and P40 in differential diagnosis of non-small cell lung carcinoma. Pakistan Journal of Medicine and Dentistry 2019, Vol. 8 (03).

Haider SI, Snead DR, Bari MF. Medical Students' Perceptions of Clinical Teachers as Role Model. PLoS One. 2016 Mar 9;11(3):e0150478. doi: 10.1371/journal.pone.0150478. PMID: 26959364; PMCID: PMC4784941. (Impact Factor= 3.234)

Bari MF, Ngo S, Bastie CC, Sheppard AM, Vatish M. Gestational diabetic transcriptomic profiling of microdissected human trophoblast. J Endocrinol. 2016 Apr;229(1):47-59. doi: 10.1530/JOE-15-0424. Epub 2016 Feb 11. PMID: 26869332. (Impact Factor= 4.498)

Haider SI, Johnson N, Thistlethwaite JE, Fagan G, Bari MF. WATCH: Warwick Assessment insTrument for Clinical teacHing: Development and testing. Med Teach. 2015 Mar;37(3):289-95. doi: 10.3109/0142159X.2014.947936. Epub 2014 Aug 26. PMID: 25155842. (Impact factor=2.045)

Bari MF, Weickert MO, Sivakumar K, James SG, Snead DR, Tan BK, Randeva HS, Bastie CC, Vatish M. Elevated soluble CD163 in gestational diabetes mellitus: secretion from human placenta and adipose tissue. PLoS One. 2014 Jul 1;9(7):e101327. doi: 10.1371/journal.pone.0101327. PMID: 24983948; PMCID: PMC4077809. (Impact Factor= 3.234)

Patel V, Adya R, Chen J, Ramanjaneya M, Bari MF, Bhudia SK, Hillhouse EW, Tan BK, Randeva HS. Novel insights into the cardio-protective effects of FGF21 in lean and obese rat hearts. PLoS One. 2014 Feb 3;9(2):e87102. doi: 10.1371/journal.pone.0087102. PMID: 24498293; PMCID: PMC3911936. (Impact Factor= 3.234)

Bari MF, Brown H, Nicholson AG, Kerr KM, Gosney JR, Wallace WA, Soomro I, Muller S, Peat D, Moore JD, Ward LA, Freidin MB, Lim E, Vatish M, Snead DR. BAI3, CDX2 and VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas. Histopathology. 2014 Mar;64(4):547-56. doi: 10.1111/his.12278. Epub 2013 Nov 25. PMID: 24266897. (Impact Factor= 3.453)

Sirinukunwattana K, Savage RS, Bari MF, Snead DR, Rajpoot NM. Bayesian hierarchical clustering for studying cancer gene expression data with unknown statistics. PLoS One. 2013 Oct 23;8(10):e75748. doi: 10.1371/journal.pone.0075748. PMID: 24194826; PMCID: PMC3806770. (Impact Factor= 3.234)

Sivakumar K, Bari MF, Adaikalakoteswari A, Guller S, Weickert MO, Randeva HS, Grammatopoulos DK, Bastie CC, Vatish M. Elevated fetal adipsin/acylation-stimulating protein (ASP) in obese pregnancy: novel placental secretion via Hofbauer cells. J Clin Endocrinol Metab. 2013 Oct;98(10):4113-22. doi: 10.1210/jc.2012-4293. Epub 2013 Aug 16. PMID: 23956345; PMCID: PMC3790615. (Impact Factor= 6.209)

Tan BK, Sivakumar K, Bari MF, Vatish M, Randeva HS. Lower cerebrospinal fluid/plasma fibroblast growth factor 21 (FGF21) ratios and placental FGF21 production in gestational diabetes. PLoS One. 2013 Jun 3;8(6):e65254. doi: 10.1371/journal.pone.0065254. PMID: 23755203; PMCID: PMC3670883. (Impact Factor= 3.234)

Markovic D, Bari MF, Lu B, Vatish M, Grammatopoulos DK. Corticotropin-releasing hormone interacts with interleukin-1β to regulate prostaglandin H synthase-2 expression in human myometrium during pregnancy and labor. J Clin Endocrinol Metab. 2013 Jul;98(7):2864-75. doi: 10.1210/jc.2013-1094. Epub 2013 May 10. PMID: 23666959; PMCID: PMC3877764. (Impact Factor= 6.209)

Previous/Current Research Funding (Including VCSFI funding):

1. Whole exome sequencing for identification of small mutations and derivation of mutation specific induced pluripotent stem cells from Duchenne Muscular dystrophy Patients (Ref No. 20-14668/NRPU/R&D/HEC/2021) – PKR 5.7 million
2. Correlation of HLA-1 Alleles, Mica Polymorphism and salivary cytokine, Statherin & BCL12 expression profile with oral precancerous and cancerous lesions in comparison with healthy controls (Ref No. 20-14651/NRPU/R&D/HEC/2021) – PKR 4.9 million
3. Identification of biomarkers for the diagnosis of Polycystic Ovarian Syndrome Patients (Ref No. 7155/ Sindh/ NRPU/ R&D/ HEC/ 2017) – PKR 8.7 million
4. Development of Peer Mentoring Program for Postgraduate Medical Residency in Pakistan (Ref No. 5220/ Sindh/ NRPU/ R&D/ HEC/ 2016) – PKR 0.9 million
5. Validation of a clinical teaching instrument for doctors and trainees in Pakistan (Ref No. 5221/ Sindh/ NRPU/ R&D/ HEC/ 2016) – PKR0.9 million

CONFERENCE PRESENTATIONS

• Motta-Mejia C, Bari MF, Kouser L, Gill M, Neuhaus A, Couch Y, Zhang W, Kandzija N, Cerdeira AS, Redman C, Kishore U, Vatish M. Placental capillary pericytes release more exosomes and immunomodulatory and growth factors in response to hypoxia. IFPA, Tokyo, Japan, 2018
• Kashan F, Bari MF and Khalid, Z. Meta-analysis of markers associated with Gestational Diabetes Mellitus. Gynecological Endocrinology World Congress, Florence, Italy, 2018
• Khalid Z, Bari MF and Kashan F. Circulating biomarkers for the diagnosis of Polycystic Ovarian Syndrome patients: A Meta-analysis. Gynecological Endocrinology World Congress, Florence, Italy, 2018
• Bari MF. and Vatish, M. F. Transcriptomic profiling of gestational diabetes and obese syncytiotrophoblasts. 15th annual Conference of South Asian Federation of Endocrine Societies, Lahore, Pakistan, 2017.
• Nehad, Bari MF, Mirza T, Farooqui WA, Razaq A, Mughal.
• MN, Bukhari U, Sharafat S. Comparative study of immunohistochemical markers for subtyping and prognostication of adeno & squamous cell lung carcinomas, DUHS, Karachi, 2017
• Alkawafi I, Bari MF, Vatish M and Grammatopoulos DK. Gestational diabetes is associated with increased activity of the placental mTOR pathway: characterisation of mechanisms controlling trophoblast differentiation and endocrine function. Society for Gynecologic Investigation annual meeting, Italy, 2014
• Bari MF. BAI3, CDX2 & VIL1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas. PAP conference 2013. Lahore, Pakistan.
• Ebert B, Bari MF, Snead D and Mitchell D. Role of transcription factors ASCL1 and HES1 expression in diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH) and pulmonary carcinoids. September, 2013, Barcelona, Spain.
• Bari MF, Grammatopoulos DK, Quenby S, Brosens JJ, Bastie CC, Vatish M. Microarray analysis of laser-capture microdissected syncytiotrophoblast reveals unique differences in gene expression between normal and IUGR pregnancies. Annual Academic Meeting in Obstetrics and Gynecology 2012, London, UK.
• Bari MF, Nicholson AG, Kerr KM, Gosney JR, Freidin MB, Moore JD, Vatish M and Snead DRJ. Biomarkers for the classification of highly malignant neuroendocrine lung carcinomas. Congress of International Academy of Pathology, Cape Town, South Africa, 2012.
• Bari MF and Snead, DRJ. In silico analysis of gene expression analysis of small cell lung cancer. ERS congress2010, Barcelona, Spain.
• Bari MF, Moore JD, Zehnder D, Bird H and Snead DRJ. Analysis of gene expression array data to identify biomarkers specific to small cell lung cancer. AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer 2010, Coronado, USA.
• Bari MF, Moore JD, Zehnder D, Bird H and Snead DRJ. Molecular Characteristics of Small Cell Lung Carcinoma. Society of Great Britain and Ireland Winter Meeting 2010, London, UK.
• Poorna CSBN, Rajpoot NM, Bari MF, Snead DRJ. Characterisation of morphological patterns in pulmonary neuroendocrine carcinoma histology images. Microscopy Image Analysis for Biomedical Applications 2010, London, UK.